If you plug straight in with no pedals then the problem might be one of your pedals, a cable, or your power for the pedals, or something else.

Still could be a preamp tube, start troubleshooting.

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Gibson Explorer, Mesa Mark III Series 300 (Coliseum), Mesa 4x12 standard slant and straight with V30, Boss TU-2, NS-2, CH-1, Aphex guitar Exciter, Monster Cables, D'addario EXL140 strings, Jim Dunlop straplocks, Jim Dunlop JazzIII picks, Eurotubes supplied by JJ Electronics, Furman PL plus II