I tried out the Powerblock and was not impressed with the sound. I agree with DanteDMC, the POD will sound better with some tubes warming them up. My PODxt Live sounds killer through my Cobra but not so hot through my Mesa 2:90, even though it is a tube poweramp.

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Live Rig
GUITARS -- 2 Burny RLC-70S's (Japanese Les Paul Custom copies) and a Japanese-made Fender Strat.Stage guitars
FX - Dunlop 95Q Crybaby wah - Vox TonelabLE multi-FX processor/amp-modeler - Boss GE-7 EQ - Boss DD-5 Digital Delay - Boss NS-2 Noise Suppressor.
AMPLIFICATION - Modded Ampeg VT-22 (V4) 100-watt head (6L6GC power tubes) - Soldano 4X12 straight cabinet loaded w/Eminence Legend speakers.